Neuroscientists have shown that calorie-reduced diets stop the normal rise and fall in activity levels of close to 900 different genes linked to aging and memory formation in the brain.
Neuroscientists at NYU Langone Medical Center have shown that calorie-reduced diets stop the normal rise and fall in activity levels of close to 900 different genes linked to aging and memory formation in the brain.
In a presentation prepared for the Society for Neuroscience annual meeting in Washington, D.C., researchers say their experimental results, conducted in female mice, suggest how diets with fewer calories derived from carbohydrates likely deter some aspects of aging and chronic diseases in mammals, including humans.
"Our study shows how calorie restriction practically arrests gene expression levels involved in the aging phenotype -- how some genes determine the behavior of mice, people, and other mammals as they get old," says senior study investigator and NYU Langone neuroscientist, Stephen D. Ginsberg, PhD. Ginsberg cautions that the study does not mean calorie restriction is the "fountain of youth," but that it does "add evidence for the role of diet in delaying the effects of aging and age-related disease."
While restrictive dietary regimens have been well-known for decades to prolong the lives of rodents and other mammals, their effects in humans have not been well understood. Benefits of these diets have been touted to include reduced risk of human heart disease, hypertension, and stroke, Ginsberg notes, but the widespread genetic impact on the memory and learning regions of aging brains has not before been shown. Previous studies, he notes, have only assessed the dietary impact on one or two genes at a time, but his analysis encompassed more than 10,000 genes.
Ginsberg, an associate professor at NYU Langone and its affiliated Nathan S. Kline Institute for Psychiatric Research, says the research "widens the door to further study into calorie restriction and anti-aging genetics."
For the study, female mice, which like people are more prone to dementia than males, were fed food pellets that had 30 percent fewer calories than those fed to other mice. Tissue analyses of the hippocampal region, an area of the brain affected earliest in Alzheimer's disease, were performed on mice in middle and late adulthood to assess any difference in gene expression over time.
GMT 08:43 2018 Tuesday ,11 December
Huawei executive's bail hearing to resume TuesdayGMT 16:27 2018 Monday ,10 December
Russian ex-policeman convicted of killing almost 80 womenGMT 10:10 2018 Thursday ,22 November
Drug smuggler freed from Bali jail arrives home in AustraliaGMT 11:58 2018 Sunday ,11 November
Australian police arrest woman for needles inside strawberriesGMT 07:44 2018 Friday ,09 November
Imelda Marcos faces prison after corruption convictionsGMT 08:48 2018 Thursday ,01 November
Peru opposition leader Fujimori to be jailed for 36 monthsGMT 12:45 2018 Thursday ,20 September
Palestinian writer released after serving time in Israeli prison for her poemGMT 11:42 2018 Tuesday ,23 January
80 pc school janitors found working without work visaMaintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Send your comments
Your comment as a visitor