gene expression affects bp
Last Updated : GMT 09:07:40
Egypt Today, egypt today
Egypt Today, egypt today
Last Updated : GMT 09:07:40
Egypt Today, egypt today

Risk of clots during pregnancy

Gene expression affects BP

Egypt Today, egypt today

Egypt Today, egypt today Gene expression affects BP

The thromboxane synthase gene codes for this enzyme
Washington - Arabstoday

The thromboxane synthase gene codes for this enzyme Washington - Arabstoday Researchers have discovered that changes in the gene expression of a key enzyme may contribute to high blood pressure and increase susceptibility to forming blood clots in pregnant women with preeclampsia. These findings could provide clues to the best treatment approaches for high blood pressure and the formation of blood clots that can block blood flow to a pregnant woman’s internal organs and lead to organ failure. Virginia Commonwealth University School of Medicine researchers have been working to determine the root cause of preeclampsia on the molecular level and have now identified that epigenetic mechanisms may be at play. Epigenetics refers to changes in gene expression that are mediated through mechanisms other than changes in the DNA sequence. The VCU team reported that thromboxane synthase – an important inflammatory enzyme – is increased in the blood vessels of expectant mothers with preeclampsia. The thromboxane synthase gene codes for this enzyme, which is involved in several processes including cardiovascular disease and stroke. This enzyme results in the synthesis of thromboxane, which increases blood pressure and causes blood clots. “The present work is unique because it opens up a new concept as to the cause and subsequent consequences of preeclampsia relating to epigenetics,” said corresponding author Scott W. Walsh, Ph.D., professor in the VCU Department of Obstetrics and Gynecology. “It is the first study to show that epigenetic alterations in the blood vessels of the mother are related to preeclampsia,” Walsh stated. According to Walsh, one of the main epigenetic mechanisms is methylation of the DNA, which controls the expression of genes. The increase of this enzyme in the blood vessels is related to reduced DNA methylation and the infiltration of neutrophils into the blood vessels. Neutrophils are white blood cells that normally help fight infection. In the future, Walsh said some potential treatments for preeclampsia may include inhibition of thromboxane synthase, blockade of thromboxane receptors or dietary supplementation with folate. He said that folate supplementation could increase methylation donors to protect against adverse changes in DNA methylation that affect expression of the thromboxane synthase enzyme. The study was published online this week in Hypertension, a journal of the American Heart Association.  

egypttoday
egypttoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

gene expression affects bp gene expression affects bp



GMT 09:51 2016 Tuesday ,29 March

Back to drawing board for new father Murray

GMT 09:17 2017 Monday ,13 February

RAK police seek help to locate missing girl

GMT 21:52 2011 Monday ,08 August

Leverkusen\'s Giefer hospitalised

GMT 23:05 2017 Wednesday ,25 January

Millions travel for China’s Lunar New Year festival

GMT 23:06 2017 Tuesday ,24 January

Pakistan military tests nuclear-capable missile

GMT 11:34 2017 Tuesday ,14 February

Artist makes NY fashion week debut on a bus

GMT 14:35 2018 Monday ,22 January

Azza Fahmy Jewellery announces UK store launch

GMT 07:41 2014 Wednesday ,19 March

Nail brand The Lacquer Lab launches

GMT 15:19 2011 Tuesday ,02 August

Orwellian Barton forced to train alone by Newcastle

GMT 12:25 2016 Wednesday ,14 December

Evaluation of Participating Companies Goes in Full Swing

GMT 13:37 2017 Monday ,25 December

Abducted Yemenis kept in chains in Houthi jails
 
 Egypt Today Facebook,egypt today facebook  Egypt Today Twitter,egypt today twitter Egypt Today Rss,egypt today rss  Egypt Today Youtube,egypt today youtube  Egypt Today Youtube,egypt today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©

egypttoday egypttoday egypttoday egypttoday
egypttoday egypttoday egypttoday
egypttoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
egypttoday, Egypttoday, Egypttoday