fish oil could cure leukaemia
Last Updated : GMT 09:07:40
Egypt Today, egypt today
Egypt Today, egypt today
Last Updated : GMT 09:07:40
Egypt Today, egypt today

Cancer breakthrough

Fish oil could cure Leukaemia

Egypt Today, egypt today

Egypt Today, egypt today Fish oil could cure Leukaemia

Fish oil
London - Arabstoday

Fish oil London - Arabstoday A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers. The statement follows research where mice with leukemia-causing cells who were treated with the fish oil component were completely cured of the disease - with no relapse. The compound - named delta-12-protaglandin J3, or D12-PGJ3 - targeted and killed the stem cells of chronic myelogenous leukemia, or CML.It is produced from an Omega-3 fatty acid found in fish and fish oil. Sandeep Prabhu, associate professorof immunology and molecular toxicology in the Department of Veterinary and Medical Sciences at Penn State said: 'Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants. 'But we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice.' He added: 'The important thing is that the mice were completely cured of leukemia with no relapse.' The researchers, who released their findings in the current issue of Blood, said the compound kills cancer-causing stem cells in the mice's spleen and bone marrow. Specifically, it activates a gene in the leukemia stem cell that programs the cell's own death. Killing the stem cells in leukemia, a cancer of the white blood cells, is important because stem cells can divide and produce more cancer cells, as well as create more stem cells. The current therapy for CML extends the patient’s life by keeping the number of leukemia cells low. But the drugs fail to completely cure the disease because they do not target leukemia stem cells. Robert Paulson, associate professor of veterinary and biomedical sciences, who co-directed this research with Prabhu, said of the existing treatment: 'The patients must take the drugs continuously... If they stop, the disease relapses because the leukemia stem cells are resistant to the drugs.' Current treatments are also unable to kill the leukemia stem cells. 'These stem cells can hide from the treatment, and a small population of stem cells give rise to more leukemia cells,' said Paulson. 'So, targeting the stem cells is essential if you want to cure leukemia.' During the experiments, the researchers injected each mouse with about 600 nanograms of fish oil compound D12-PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse. The researchers focused on D12-PGJ3 because it killed the leukemia stem cells, but had the least number of side effects. They are currently working to determine whether the compound can be used to treat the terminal stage of CML, referred to as Blast Crisis. There are no drugs available that can treat the disease when it progresses to this stage. The researchers, who applied for a patent, are also preparing to test the compound in human trials.  

egypttoday
egypttoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

fish oil could cure leukaemia fish oil could cure leukaemia



GMT 12:12 2017 Tuesday ,07 February

BMW to showcase latest models at Geneva show

GMT 09:37 2017 Tuesday ,10 October

Google finds Russian-financed content

GMT 20:08 2014 Tuesday ,08 April

Green tea extract boosts your brain power

GMT 07:09 2017 Thursday ,09 November

Al Ameri happy for winning match

GMT 00:35 2015 Wednesday ,15 April

New clue sheds some light on mysterious 'dark matter'

GMT 11:46 2017 Tuesday ,14 February

Debenhams, Aab partner for modest

GMT 08:24 2017 Sunday ,22 October

Police martyrdom to increase our coherence

GMT 21:53 2016 Sunday ,06 November

Australian Woman Kidnapped in Afghanistan

GMT 09:05 2011 Sunday ,11 September

Eterniti\'s \'joke\' car

GMT 11:53 2017 Tuesday ,05 December

Google data-saving tool aims

GMT 05:43 2015 Saturday ,26 September

Obama, Xi make climate vow but clash on rights, islands

GMT 09:55 2019 Monday ,19 August

Live an excellent atmosphere in your career

GMT 09:34 2019 Monday ,19 August

Live a positive and important atmosphere
 
 Egypt Today Facebook,egypt today facebook  Egypt Today Twitter,egypt today twitter Egypt Today Rss,egypt today rss  Egypt Today Youtube,egypt today youtube  Egypt Today Youtube,egypt today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©

egypttoday egypttoday egypttoday egypttoday
egypttoday egypttoday egypttoday
egypttoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
egypttoday, Egypttoday, Egypttoday