Fiji-born back-row Nathan Hughes is set to make his first England start after being named in the XV to face Australia at Twickenham on Saturday.
Hughes replaces Billy Vunipola after the No 8 suffered a knee injury during England's 27-14 win over Argentina last week.
The other change sees Marland Yarde come in on the wing after Elliot Daly was suspended following his red card against Argentina.
England will be bidding for a 14th straight victory and 13th in a row under Australian coach Eddie Jones against the Wallabies.
England (15-1)
England: Mike Brown; Marland Yarde, Jonathan Joseph, Owen Farrell, Jonny May; George Ford, Ben Youngs; Nathan Hughes, Tom Wood, Chris Robshaw; George Kruis, Courtney Lawes; Dan Cole, Dylan Hartley (capt), Mako Vunipola
Replacements: Jamie George, Joe Marler, Kyle Sinckler, Charlie Ewels, Teimana Harrison, Danny Care, Ben Te'o, Henry Slade
Source: AFP
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